It would be nice if 2FA remembered my browser so that I don't have to do it every single time I log in. That's how it works with Gmail and most other services that I use 2FA with. Having to use 2FA every time I log in is inconvenient enough that I won't use it here. At least twice I've configured it and turned it back off because it's such a hassle.
And since I have to log out and log in with a different email address for every single client that I help with mailgun, I need to log out and in with some frequency. (I can't remember if my log in times out so that I'd need to deal with 2fa every day.)
Another option would be to support Yubikey so that I could just push a button to log in.
Yes, this is normal practice with 2FA and it's very inconvenient to have to enter to code every time I want to log in.